Of course the common offenders would probably be, and I say probably cause I've done some of these and never had issues, manipulating the stack frame directly, unwieldy gotos, if you haven't guessed I'm a developer so I've done a lot of development on my PC, with McAfee, and done a lot of things and never had an issue with McAfee, could also be an obfuscation issue if you use a code obfuscator. Just throwing out ideas for ya!
I'd be interested to know if anyone else who uses McAfee has this issue when viewing the Leadwerks directory. I have no way of knowing if this is just an issue with my system or McAfee in general.