Leadwerks supports 350 languages, well all which can load a dll file
You just need to convert the C API headers to your language if you use a language which nobody has used yet, since so far people have used only C, C++, C#, Java, Lua, Perl, Basic, Pascal, Delphi.
Python vs Lua is often a big discussion, and the answer is that Lua is better. Lua is the easiest way to use Leadwerks Engine, and it's all in realtime.
You can also read this decent comparison of Lua vs Python:
http://lua-users.org/wiki/LuaVersusPython